Thu, 13 Jul 2000 11:33:53 -0500
"synonymous" changes are mutations in the DNA sequence that don't
change the amino acid encoded (e.g. ttc -> ttt, both encoding Phe);
"non-synonomous" mutations do change the amino acid encoded
(e.g. ttc -> tta, Phe -> Leu), and the mutant gene therefore
produces a different protein product.
So it's not a way of classifying amino acids at all...
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On Thu, 13 Jul 2000, email@example.com wrote:
In a related note: I'd like to ask if anyone on the list might know is
there is commonly agreed definition to yet an other way of amino acid
change classification: Synonymous and non-synonymous are commonly used
terms in population genetic papers to classify coding region mutations
but they are never defined. Most probably their definiton is based on
something similar to Derek's 'functional' alphabet.
Can anyone tell me if synonymous amino acid changes are _identical_ to
Derek's functional change?