PSI-BLAST

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PSIBLAST - Position Specific Iterative BLAST - iteratively searches one or more protein databases for sequences similar to one or more protein query sequences. PSIBLAST is similar to BLAST except that it uses position-specific scoring matrices (PSSMs) derived during the search.

The actual PSIBLAST tool is called blastpgp in the NCBI old version, and psiblast in the Blast+ package.

More information in NCBI's PSIBLAST tutorial.

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